Yellow-coded Mexican-American street gang faction with cross-game continuity — established in San Andreas (2004) as one of CJ's adversary factions and returning in GTA V (2013) as a recurring street-gang presence in East Los Santos.
Drug cartel led by Martin Madrazo — GTA V's most narratively load-bearing organized-crime faction, whose mid-game crisis with Trevor Philips drives some of V's most-discussed plot pivots and routes back into GTA Online's Diamond Casino Heist storyline.
GTA V's MS-13-coded Mexican-American street gang — distinct from Los Santos Vagos, anchored in East Los Santos territory and design-coded with the face-tattoo aesthetic the real-world Mara Salvatrucha is known for.
GTA V's rural family-based crime faction — a Senora Desert clan of meth-cooking brothers who serve as Trevor Philips's primary early-storyline rivals, with their ranch as one of V's most-discussed mid-act setpiece destruction sequences.
Purple-coded Black street gang faction with two-game continuity — established as CJ's primary antagonists in San Andreas (2004) and returning in GTA V (2013) as Franklin Clinton's Chamberlain Hills-area antagonist gang.
Outlaw motorcycle club whose modern incarnation runs across GTA IV's TLAD episode (2009) and recurs as an antagonist faction in GTA V — primarily Blaine County–based, with a contentious history with Trevor Philips and a Sandy Shores compound.