GTA V's mid-act armored-truck heist — a single-mission setpiece coordinated under Madrazo Cartel pressure, with Trevor flipping the target with a tow truck while Michael grabs the bag and Franklin drives the getaway.
GTA V's opening mission — a flashback bank robbery in North Yankton roughly nine years before the main story, establishing Michael's witness-protection backstory and Trevor's belief that his partner died.
GTA V's final heist mission — the Union Depository gold robbery, executed by all three protagonists with two distinct approach branches (Subtle / Obvious) that meaningfully change the gameplay shape of the closing act.
GTA V's federal-agency heist — a raid on FIB Headquarters in Los Santos with two distinct approach branches (Roof entry vs Fire crew approach), sitting as the institutional-target counterpart to V's commercial-target heists.
GTA V's first major heist — the Vangelico jewelry store robbery executed by Michael and Franklin, with Smart and Loud approach branches that establish V's heist-planning template for everything that follows.
GTA V's mid-game heist against the Merryweather Security PMC — a maritime / port-coded operation that pits Michael and Trevor against the franchise's most-recurring private military antagonist, with two approach branches and meaningful consequences for the back-half storyline.
GTA V's small-town bank heist — the Paleto Bay Bank of Liberty robbery executed by all three protagonists with heavy-armament combat and a sustained, military-grade law-enforcement response, sitting as one of V's most-discussed setpiece heists.
GTA V's first multi-protagonist switchable mission — an FIB-coordinated extraction from a Los Santos courthouse using helicopter rooftop entry, sniper cover, and cargo-plane escape, where Michael, Trevor, and Franklin all play simultaneously.